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Navigation to St Georges will take the best part of a day and in few places the depth is 1.4 m LW - 3 m HW. Currents in the river can be up to 3 kts. Tides at St Georges are about 2½ hours later than Cayenne.
There are numerous anchorage along the way where you can wait for HW to sail:
St Georges anchorage: in 5 metres in mud by the water taxi jetties (dinghy landing spot).
Fuel: in jerry cans from across the river in Brazil by dinghy or water taxi
The fishing boats along the way are very friendly.